TTFields harness physics to disrupt mitosis in cancer cells1-3
In preclinical models, TTFields have been shown to disrupt mitosis in cancer cells by exerting electric forces on their polar components (eg, microtubule spindle formation during mitosis), disrupting their normal localization (place in cell membrane) and function, ultimately leading to cell death.1-3
Explore each phase of mitosis to see the impact of TTFields
In metaphase:
TTFields impair microtubule assembly in cancer cells, leading to aberrant mitotic spindle formation.2,4 MD video
In anaphase:
TTFields disrupt the arrangement of septin at the anaphase cleavage furrow in cancer cells, inducing cytoplasmic membrane blebbing, mitotic failure, and asymmetric chromosome segregation.1,5
In telophase:
Polar organelles and macromolecules in cancer cells are pushed to the area of higher TTFields intensity when cancer cells assume an hourglass shape during telophase and cytokinesis in a process known as dielectrophoresis.4,5
Watch below to see how TTFields disrupt mitosis in cancer cells
See the enhanced effects of TTFields when used with chemotherapy
See how TTFields also interferes with cancer cell migration
References: 1. Gera N, Yang A, Holtzman TS, Lee SX, Wong ET, Swanson KD. Tumor treating fields perturb the localization of septins and cause aberrant mitotic exit. PLoS One. 2015;10(5):1-20. doi:10.1371/journal.pone.0125269 2. Giladi M, Schneiderman RS, Voloshin T, et al. Mitotic spindle disruption by alternating electric fields leads to improper chromosome segregation and mitotic catastrophe in cancer cells. Sci Rep. 2015;5:1-16. doi:10.1038/srep18046 3. Voloshin T, Kaynan N, Davidi S, et al. Tumor-treating fields (TTFields) induce immunogenic cell death resulting in enhanced antitumor efficacy when combined with anti-PD-1 therapy. Cancer Immunol Immunother. 2020;69(7):1191-1204. doi:10.1007/s00262-020-02534-7 4. Gutin PH, Wong ET. Noninvasive application of alternating electric fields in glioblastoma: a fourth cancer treatment modality. Am Soc Clin Oncol Educ Book. 2012:126-131. doi:10.14694/EdBook_AM.2012.32.122 5. Mun EJ, Babiker HM, Weinberg U, Kirson ED, Von Hoff DD. Tumor-treating fields: a fourth modality in cancer treatment. Clin Cancer Res. 2018;24(2):266-275. doi:10.1158/1078-0432.CCR-17-1117